Kathy Griffin

The comedian appeared on the show's 2010 season finale.

Stars from Adele to Miley Cyrus to Demi Lovato can't help but flip the bird when they've had enough.

'We're the last line of defense,' Carrey said of comedians.

In some pretty surprising news, it looks like Kathy Griffin is following in the footsteps of her formerFashion Police co-host, Kelly Osbourne, by quitting the E! News show.